Increased Endothelial Expression of Intercellular Adhesion Molecule-1 in Symptomatic Versus Asymptomatic Human Carotid Atherosclerotic Plaque | Zendy

Thomas J. DeGraba | Zendy; AnnaLeena Sirén | Zendy; LaRoy Penix | Zendy; Richard M. McCarron | Zendy; Ronald W. Hargraves | Zendy; Suman L. Sood | Zendy; Karen D. Pettigrew | Zendy; John M. Hallenbeck | Zendy

Open Access

Increased Endothelial Expression of Intercellular Adhesion Molecule-1 in Symptomatic Versus Asymptomatic Human Carotid Atherosclerotic Plaque

Author(s) -

Thomas J. DeGraba,

AnnaLeena Sirén,

LaRoy Penix,

Richard M. McCarron,

Ronald W. Hargraves,

Suman L. Sood,

Karen D. Pettigrew,

John M. Hallenbeck

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.7.1405

Subject(s) - medicine , asymptomatic , carotid endarterectomy , intercellular adhesion molecule 1 , stenosis , inflammation , pathology , vascular disease , endothelial activation , fibrous cap , thrombosis , endothelium , icam 1 , gastroenterology , cell adhesion molecule , immunology

The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Evidence suggests that mediators of inflammation are not only instrumental in the formation of plaque but may also be involved in the rapid progression of atheromatous lesions leading to plaque fissuring, endothelial injury, and intraluminal thrombosis. Our goal is to determine whether intercellular adhesion molecule-1 (ICAM-1), a known component of the inflammatory pathway, is preferentially expressed on symptomatic versus asymptomatic carotid plaques.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research