Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Endotoxin-Induced Cerebral Hyperemia | Zendy

Hirotsugu Okamoto | Zendy; Osamu Ito | Zendy; Richard J. Roman | Zendy; Antal G. Hudetz | Zendy

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Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Endotoxin-Induced Cerebral Hyperemia

Author(s) -

Hirotsugu Okamoto,

Osamu Ito,

Richard J. Roman,

Antal G. Hudetz

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.6.1209

Subject(s) - nitric oxide synthase , cyclooxygenase , medicine , nitric oxide , lipopolysaccharide , endocrinology , cerebral blood flow , dexamethasone , pharmacology , vasodilation , endothelial nos , enzyme , chemistry , biochemistry , enos

Bacterial lipopolysaccharide (LPS), an endotoxin, has been reported to induce the expression of inducible isoforms of both nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in various cell types. LPS is also known to dilate systemic vasculature, including cerebral vessels. This study aimed to determine to what extent LPS induces iNOS and COX-2 expression in the brain and whether NO and/or cyclooxygenase metabolites derived from iNOS and/or COX-2 contribute to the LPS-induced cerebral hyperemia.

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