Plasminogen Activators Potentiate Thrombin-Induced Brain Injury | Zendy

Bryan E. Figueroa | Zendy; Richard F. Keep | Zendy; A. Lorris Betz | Zendy; Julian T. Hoff | Zendy

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Plasminogen Activators Potentiate Thrombin-Induced Brain Injury

Author(s) -

Bryan E. Figueroa,

Richard F. Keep,

A. Lorris Betz,

Julian T. Hoff

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.6.1202

Subject(s) - medicine , thrombin , intracerebral hemorrhage , tissue plasminogen activator , pharmacology , urokinase , fibrinolysis , brain edema , edema , context (archaeology) , anesthesia , platelet , subarachnoid hemorrhage , biology , paleontology

Evidence suggests that cerebral edema following intracerebral hemorrhage (i.c.h.) results from a mass effect in combination with neurotoxic injury from clot-derived substrates such as thrombin. Thrombolytics can compete for thrombin inhibitors endogenous to the brain. This study examines the effect of intracerebral infusion of thrombolytics, tissue plasminogen activator (tPA), and urokinase (uPA), individually and in combination with thrombin.

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