Evidence For Genetic Variance in White Matter Hyperintensity Volume in Normal Elderly Male Twins
Author(s) -
Dorit Carmelli,
Charles DeCarli,
Gary E. Swan,
Lisa M. Jack,
Terry Reed,
Philip A. Wolf,
Bruce L. Miller
Publication year - 1998
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.29.6.1177
Subject(s) - heritability , medicine , hyperintensity , concordance , confidence interval , white matter , brain size , twin study , subclinical infection , magnetic resonance imaging , radiology , biology , genetics
White matter hyperintensities (WMHs), as detected by MRI, are common among the elderly and are frequently interpreted as representing a subclinical form of ischemic brain damage. We used volumetric MR techniques to investigate the contribution of genes and the environment to measures of brain morphology in a sample of community dwelling elderly male twins.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom