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Evidence For Genetic Variance in White Matter Hyperintensity Volume in Normal Elderly Male Twins
Author(s) -
Dorit Carmelli,
Charles DeCarli,
Gary E. Swan,
Lisa M. Jack,
Terry Reed,
Philip A. Wolf,
Bruce L. Miller
Publication year - 1998
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.29.6.1177
Subject(s) - heritability , medicine , hyperintensity , concordance , confidence interval , white matter , brain size , twin study , subclinical infection , magnetic resonance imaging , radiology , biology , genetics
White matter hyperintensities (WMHs), as detected by MRI, are common among the elderly and are frequently interpreted as representing a subclinical form of ischemic brain damage. We used volumetric MR techniques to investigate the contribution of genes and the environment to measures of brain morphology in a sample of community dwelling elderly male twins.

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