Dose Optimization of Intravenous Magnesium Sulfate After Acute Stroke | Zendy

Keith W. Muir | Zendy; Kennedy R. Lees | Zendy

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Dose Optimization of Intravenous Magnesium Sulfate After Acute Stroke

Author(s) -

Keith W. Muir,

Kennedy R. Lees

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.5.918

Subject(s) - medicine , tolerability , anesthesia , stroke (engine) , regimen , placebo , blood pressure , magnesium , randomized controlled trial , loading dose , surgery , adverse effect , engineering , metallurgy , mechanical engineering , materials science , alternative medicine , pathology

Parenterally administered MgSO4 is neuroprotective in standard animal models of focal cerebral ischemia and in many other paradigms of brain injury. Previous small clinical trials in stroke patients have explored the safety and tolerability of different infusion regimens. This study was undertaken to optimize the regimen for a multicenter trial.

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