Apoptosis of Motor Neurons With Induction of Caspases in the Spinal Cord After Ischemia | Zendy

Takaaki Hayashi | Zendy; Masahiro Sakurai | Zendy; Kōji Abe | Zendy; Mitsuaki Sadahiro | Zendy; K. Tabayashi | Zendy; Yasuto Itoyama | Zendy

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Apoptosis of Motor Neurons With Induction of Caspases in the Spinal Cord After Ischemia

Author(s) -

Takaaki Hayashi,

Masahiro Sakurai,

Kōji Abe,

Mitsuaki Sadahiro,

K. Tabayashi,

Yasuto Itoyama

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.5.1007

Subject(s) - tunel assay , ischemia , spinal cord , medicine , terminal deoxynucleotidyl transferase , immunohistochemistry , in situ nick end labeling , apoptosis , pathology , blot , h&e stain , nissl body , western blot , motor neuron , staining , biology , biochemistry , psychiatry , gene

Some neuronal subpopulations are especially vulnerable to ischemic injury. In the spinal cord, large motor neurons are vulnerable to ischemia and are selectively lost after transient ischemia. However, the mechanisms of the neuronal loss have been uncertain. We hypothesized that spinal motor neurons might be lost by apoptosis and investigated a possible mechanism of neuronal death by detection of double-strand breaks in genomic DNA and immunohistochemical analysis for caspases, ie, interleukin-1beta converting enzyme (ICE), Nedd-2, and CPP32.

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