Treatment With the Competitive NMDA Antagonist GPI 3000 Does Not Improve Outcome After Cardiac Arrest in Dogs | Zendy

Mark A. Helfaer | Zendy; Rebecca Ichord | Zendy; Lee J. Martin | Zendy; Patricia D. Hurn | Zendy; Alejandro Castro | Zendy; Richard J. Traystman | Zendy

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Treatment With the Competitive NMDA Antagonist GPI 3000 Does Not Improve Outcome After Cardiac Arrest in Dogs

Author(s) -

Mark A. Helfaer,

Rebecca Ichord,

Lee J. Martin,

Patricia D. Hurn,

Alejandro Castro,

Richard J. Traystman

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.4.824

Subject(s) - medicine , antagonist , nmda receptor , outcome (game theory) , anesthesia , cardiology , receptor , mathematics , mathematical economics

We previously showed that treatment with a competitive N-methyl-D-aspartate (NMDA) receptor antagonist GPI-3000 (GPI) improved short-term physiological recovery after incomplete global cerebral ischemia complicated by dense acidosis. We tested the hypothesis that GPI administered after resuscitation from cardiac arrest would improve a more long-term recovery as measured by neurobehavioral assessment and neuropathology 4 days after resuscitation.

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