Low Molecular Weight Iron in Cerebral Ischemic Acidosis In Vivo | Zendy

Diane C. Lipscomb | Zendy; Linda G. Gorman | Zendy; Richard J. Traystman | Zendy; Patricia D. Hurn | Zendy

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Low Molecular Weight Iron in Cerebral Ischemic Acidosis In Vivo

Author(s) -

Diane C. Lipscomb,

Linda G. Gorman,

Richard J. Traystman,

Patricia D. Hurn

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.2.487

Subject(s) - ischemia , medicine , phosphocreatine , intracellular ph , acidosis , in vivo , anesthesia , endocrinology , brain ischemia , high energy phosphate , saline , biochemistry , intracellular , chemistry , energy metabolism , biology , microbiology and biotechnology

Iron-catalyzed radical generation is a potentially significant mechanism by which extensive tissue acidosis exacerbates brain injury during ischemia/reperfusion. We hypothesized that levels of low-molecular-weight (LMW) iron increase during in vivo global cerebral ischemia in a pH-dependent manner, potentially catalyzing oxidant injury. The present study quantified regional differences in LMW iron during global cerebral incomplete ischemia and determined whether augmenting the fall in ischemic tissue pH with hyperglycemia also amplifies free iron availability.

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