Expression and Vascular Effects of Cyclooxygenase-2 in Brain | Zendy

Johnny E. Brian | Zendy; Steven A. Moore | Zendy; Frank M. Faraci | Zendy

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Expression and Vascular Effects of Cyclooxygenase-2 in Brain

Author(s) -

Johnny E. Brian,

Steven A. Moore,

Frank M. Faraci

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.12.2600

Subject(s) - medicine , in vivo , cyclooxygenase , western blot , dexamethasone , lipopolysaccharide , cerebrospinal fluid , leptomeninges , prostaglandin , prostaglandin e2 , endocrinology , microglia , pharmacology , inflammation , central nervous system , biology , biochemistry , enzyme , microbiology and biotechnology , gene

Cyclooxygenase-2 (COX-2) is an inducible isoform of cyclooxygenase. Several types of brain cells in culture can express COX-2 when treated with lipopolysaccharide (LPS) or some cytokines. LPS produces dilatation of cerebral arterioles in vivo through a mechanism that is partially inhibited by indomethacin. In the present study we examined the hypothesis that LPS causes increased expression of COX-2 in brain as well as COX-2-dependent dilatation of cerebral arterioles.

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