Role of Blood Clot Formation on Early Edema Development After Experimental Intracerebral Hemorrhage | Zendy

Guohua Xi | Zendy; Kenneth R. Wagner | Zendy; Richard F. Keep | Zendy; Ya Hua | Zendy; Gabrielle M. de CourtenMyers | Zendy; Joseph P. Broderick | Zendy; Thomas G. Brott | Zendy; Julian T. Hoff | Zendy

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Role of Blood Clot Formation on Early Edema Development After Experimental Intracerebral Hemorrhage

Author(s) -

Guohua Xi,

Kenneth R. Wagner,

Richard F. Keep,

Ya Hua,

Gabrielle M. de CourtenMyers,

Joseph P. Broderick,

Thomas G. Brott,

Julian T. Hoff

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.12.2580

Subject(s) - medicine , edema , intracerebral hemorrhage , cerebral edema , anesthesia , white matter , heparin , magnetic resonance imaging , subarachnoid hemorrhage , radiology

Blood "toxicity" is hypothesized to induce edema and brain tissue injury following intracerebral hemorrhage (ICH). Lobar ICH in pigs produces rapidly developing, marked perihematomal edema (>10% increase in water content) associated with clot-derived plasma protein accumulation. Coagulation cascade activation and, specifically, thrombin itself contribute to edema development during the first 24 hours after gray matter ICH in rats. In the present study, we sought to determine whether blood clot formation is necessary for edema development by comparing intracerebral infusions of heparinized and unheparinized blood in pig (white matter) and in rat (gray matter). We also examined heparin's effect on thrombin-induced gray matter edema.

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