Endothelial Cell Culture From Human Cerebral Cavernous Malformations | Zendy

Nikolay I. Baev | Zendy; Issam A. Awad | Zendy

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Endothelial Cell Culture From Human Cerebral Cavernous Malformations

Author(s) -

Nikolay I. Baev,

Issam A. Awad

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.11.2426

Subject(s) - immunocytochemistry , medicine , microbiology and biotechnology , cd31 , trypsinization , pathology , endothelial stem cell , von willebrand factor , biology , immunology , trypsin , immunohistochemistry , in vitro , biochemistry , enzyme , platelet

The cerebral cavernous malformation (CCM) is a common and frequently unrecognized cause of stroke and epilepsy. It consists of blood-filled caverns lined by endothelial cells (EC) and devoid of mature vessel wall structure. Cultured EC obtained from CCM may express phenotypic and genotypic alterations contributing to CCM pathogenesis. We report the first successful isolation and growth in vitro of primary EC lines from human CCM lesions.

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