Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain | Zendy

Gary A. Rosenberg | Zendy; Eduardo Y. Estrada | Zendy; John E. Dencoff | Zendy

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Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

Author(s) -

Gary A. Rosenberg,

Eduardo Y. Estrada,

John E. Dencoff

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.10.2189

Subject(s) - medicine , gelatinase , blood–brain barrier , matrix metalloproteinase , zymography , vascular permeability , extravasation , evans blue , anesthesia , ischemia , endocrinology , pathology , central nervous system

Reperfusion disrupts cerebral capillaries, causing cerebral edema and hemorrhage. Middle cerebral artery occlusion (MCAO) induces the matrix-degrading metalloproteinases, but their role in capillary injury after reperfusion is unknown. Matrix metalloproteinases (MMPs) and tissue inhibitors to metalloproteinases (TIMPs) modulate capillary permeability. Therefore, we measured blood-brain barrier (BBB) permeability, brain water and electrolytes, MMPs, and TIMPs at multiple times after reperfusion.

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