Cationic Polymer and Lipids Enhance Adenovirus-Mediated Gene Transfer to Rabbit Carotid Artery | Zendy

Ḱazunori Toyoda | Zendy; Hiroaki Ooboshi | Zendy; Yi Chu | Zendy; A Fasbender | Zendy; Beverly L. Davidson | Zendy; Michael J. Welsh | Zendy; Donald D. Heistad | Zendy

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Cationic Polymer and Lipids Enhance Adenovirus-Mediated Gene Transfer to Rabbit Carotid Artery

Author(s) -

Ḱazunori Toyoda,

Hiroaki Ooboshi,

Yi Chu,

A Fasbender,

Beverly L. Davidson,

Michael J. Welsh,

Donald D. Heistad

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.10.2181

Subject(s) - transgene , adenoviridae , genetic enhancement , microbiology and biotechnology , endothelium , nitric oxide synthase , biology , chemistry , biochemistry , gene , enzyme , endocrinology

Improvement of efficiency of gene transfer to endothelium could be useful for several applications. We tested the hypothesis that cationic nonviral molecules augment adenovirus-mediated gene transfer to blood vessels, perhaps by alteration of the surface charge of adenovirus and facilitation of binding to endothelium.

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