Optimal Depth and Duration of Mild Hypothermia in a Focal Model of Transient Cerebral Ischemia | Zendy

Carolina M. Maier | Zendy; Kristine vB. Ahern | Zendy; Ming Cheng | Zendy; Jong Eun Lee | Zendy; Midori A. Yenari | Zendy; Gary K. Steinberg | Zendy

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Optimal Depth and Duration of Mild Hypothermia in a Focal Model of Transient Cerebral Ischemia

Author(s) -

Carolina M. Maier,

Kristine vB. Ahern,

Ming Cheng,

Jong Eun Lee,

Midori A. Yenari,

Gary K. Steinberg

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.10.2171

Subject(s) - medicine , hypothermia , anesthesia , neuroprotection , stroke (engine) , ischemia , occlusion , surgery , cardiology , mechanical engineering , engineering

Mild hypothermia is possibly the single most effective method of cerebroprotection developed to date. However, many questions regarding mild hypothermia remain to be addressed before its potential implementation in the treatment of human stroke. Here we report the results of 2 studies designed to determine the optimal depth and duration of mild hypothermia in focal stroke and its effects on infarct size, neurological outcome, programmed cell death, and inflammation.

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