Citicoline Treatment for Experimental Intracerebral Hemorrhage in Mice | Zendy

Wayne M. Clark | Zendy; Lisa Gunion-Rinker | Zendy; Nikola Lessov | Zendy; Kristin Hazel | Zendy

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Citicoline Treatment for Experimental Intracerebral Hemorrhage in Mice

Author(s) -

Wayne M. Clark,

Lisa Gunion-Rinker,

Nikola Lessov,

Kristin Hazel

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.10.2136

Subject(s) - citicoline , medicine , intracerebral hemorrhage , anesthesia , hematoma , neuroprotection , saline , placebo , lesion , surgery , subarachnoid hemorrhage , pharmacology , pathology , alternative medicine

Citicoline sodium (cytidine-5'-diphosphocholine) has been shown previously to reduce ischemic injury in focal central nervous system models. Intracerebral hemorrhage (ICH) appears to be associated with an area of edema and ischemic injury surrounding the hematoma that may be reduced by neuroprotective therapy. The present study was designed to test whether treatment with citicoline reduces ischemic injury and improves functional neurological outcome in an experimental model of ICH.

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