A Longitudinal Prospective Study of Soluble Adhesion Molecules in Acute Stroke | Zendy

Andreas Bitsch | Zendy; W. Klene | Zendy; L. Murtada | Zendy; Hilmar Prange | Zendy; Peter Rieckmann | Zendy

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A Longitudinal Prospective Study of Soluble Adhesion Molecules in Acute Stroke

Author(s) -

Andreas Bitsch,

W. Klene,

L. Murtada,

Hilmar Prange,

Peter Rieckmann

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.10.2129

Subject(s) - medicine , cell adhesion molecule , ischemia , stroke (engine) , adhesion , intercellular adhesion molecule 1 , pathophysiology , brain ischemia , selectin , soluble cell adhesion molecules , endothelial activation , e selectin , endothelium , cell adhesion , immunology , organic chemistry , mechanical engineering , chemistry , engineering

Activation of endothelial cells is a consequence of cerebral ischemia and leads to the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin, which can be released into the blood. This study aimed to define the kinetics of soluble adhesion molecule serum levels after cerebral ischemia and their correlation with the extent of neurological deficits, clinical outcome, and infarct volume as measured on CT scans. Methods-Plasma levels of soluble (s) ICAM-1, sVCAM-1, and sE-selectin were repeatedly determined by ELISA in 38 patients during a period of 14 days after acute cerebral ischemia.

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