Gender-Linked Brain Injury in Experimental Stroke | Zendy

Nabil J. Alkayed | Zendy; Izumi Harukuni | Zendy; Alane S. Kimes | Zendy; Edythe D. London | Zendy; Richard J. Traystman | Zendy; Patricia D. Hurn | Zendy

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Gender-Linked Brain Injury in Experimental Stroke

Author(s) -

Nabil J. Alkayed,

Izumi Harukuni,

Alane S. Kimes,

Edythe D. London,

Richard J. Traystman,

Patricia D. Hurn

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.1.159

Subject(s) - medicine , ischemia , cerebral blood flow , stroke (engine) , middle cerebral artery , infarction , laser doppler velocimetry , hemodynamics , blood flow , cerebral infarction , cardiology , endocrinology , anesthesia , myocardial infarction , mechanical engineering , engineering

Premenopausal women are at lower risk than men for stroke, but the comparative vulnerability to tissue injury once a cerebrovascular incident occurs is unknown. We hypothesized that female rats sustain less brain damage than males during experimental focal ischemia and that the gender difference in ischemic outcome can be eliminated by ovariectomy.

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