Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats | Zendy

Carrie G. Markgraf | Zendy; Nelson L. Velayo | Zendy; Michael P. Johnson | Zendy; Deborah R. McCarty | Zendy; Shujaath Medhi | Zendy; Jack R. Koehl | Zendy; Paula A. Chmielewski | Zendy; Matthew D. Linnik | Zendy

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Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats

Author(s) -

Carrie G. Markgraf,

Nelson L. Velayo,

Michael P. Johnson,

Deborah R. McCarty,

Shujaath Medhi,

Jack R. Koehl,

Paula A. Chmielewski,

Matthew D. Linnik

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.1.152

Subject(s) - medicine , ischemia , calpain , middle cerebral artery , pharmacodynamics , stroke (engine) , brain ischemia , anesthesia , occlusion , therapeutic window , ex vivo , pharmacology , in vivo , cardiology , pharmacokinetics , enzyme , mechanical engineering , biochemistry , chemistry , microbiology and biotechnology , engineering , biology

Stroke patients often experience a significant temporal delay between the onset of ischemia and the time to initiation of therapy. Thus, there is a need for neuroprotectants with a long therapeutic window of opportunity. The efficacy of a potent, central nervous system-penetrating calpain inhibitor (MDL 28,170) was evaluated in a temporary model of focal cerebral ischemia to determine the window of opportunity for intracellular protease inhibition.

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