Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity. | Zendy

Hugh S. Markus | Zendy; Patrick Vallance | Zendy; Martin M. Brown | Zendy

Open Access

Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity.

Author(s) -

Hugh S. Markus,

Patrick Vallance,

Martin M. Brown

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.9.1760

Subject(s) - medicine , hyperventilation , hypercapnia , cerebral blood flow , middle cerebral artery , anesthesia , hypocapnia , vasodilation , cerebral circulation , aspirin , cyclooxygenase , blood flow , ischemia , acidosis , chemistry , biochemistry , enzyme

Prostaglandins are believed to play an important role in maintenance of cerebral blood flow and possibly in the vasodilatory response to carbon dioxide. Therefore, the nonsteroidal anti-inflammatory drugs and aspirin, which inhibit cyclooxygenase, might be expected to reduce cerebral blood flow and the response to hypercapnia. This could induce cerebral ischemia in patients with a hemodynamically critical circulation. It would also interfere with the measurement of cerebrovascular reserve using carbon dioxide.

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