Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats. | Zendy

Stéphane Blot | Zendy; JeanFrançois Arnal | Zendy; Yichun Xu | Zendy; Françoise Gray | Zendy; J B Michel | Zendy

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Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats.

Author(s) -

Stéphane Blot,

JeanFrançois Arnal,

Yichun Xu,

Françoise Gray,

J B Michel

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.8.1666

Subject(s) - medicine , spinal cord , nitric oxide synthase , nitric oxide , blood pressure , central nervous system , fibrinoid necrosis , anesthesia , stroke (engine) , spinal cord injury , white matter , endocrinology , pathology , magnetic resonance imaging , mechanical engineering , vasculitis , disease , psychiatry , engineering , radiology

Chronic hypertension is a major predisposing factor for stroke in humans. It has recently been shown that long-term inhibition of nitric oxide synthase activity causes a gradual time-dependent increase in arterial blood pressure in rats. We used this new animal model of chronic hypertension to study the occurrence and spatial features of infarcts in the central nervous system.

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