Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments. | Zendy

Tadahiko Ishiyama | Zendy; Shuji Dohi | Zendy; Hiroki Iida | Zendy; Shigeru Akamatsu | Zendy; Shuichiro Ohta | Zendy; H Shimonaka | Zendy

Open Access

Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.

Author(s) -

Tadahiko Ishiyama,

Shuji Dohi,

Hiroki Iida,

Shigeru Akamatsu,

Shuichiro Ohta,

H Shimonaka

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.8.1644

Subject(s) - nicorandil , glibenclamide , vasodilation , methylene blue , medicine , cromakalim , potassium channel opener , in vivo , anesthesia , potassium channel , pharmacology , endocrinology , chemistry , biochemistry , biology , microbiology and biotechnology , photocatalysis , diabetes mellitus , catalysis

Nicorandil, a potent antianginal agent characterized as a potassium channel opener, could produce cerebrovascular dilation in in vitro studies. Our aim was to investigate the pharmacologic response to the topical application of nicorandil on the vasomotor tone of pial vessels in vivo. To elucidate its mechanism, we also studied the inhibitory action of methylene blue and glibenclamide against nicorandil-induced vasodilation.

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