Increased expression of ICAM-1 during reoxygenation in brain endothelial cells. | Zendy

David C. Hess | Zendy; Wei Zhao | Zendy; James E. Carroll | Zendy; M McEachin | Zendy; K D Buchanan | Zendy

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Increased expression of ICAM-1 during reoxygenation in brain endothelial cells.

Author(s) -

David C. Hess,

Wei Zhao,

James E. Carroll,

M McEachin,

K D Buchanan

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.7.1463

Subject(s) - medicine , hypoxia (environmental) , icam 1 , western blot , northern blot , thrombolysis , endothelial stem cell , pharmacology , messenger rna , ischemia , microbiology and biotechnology , andrology , immunology , endocrinology , cell adhesion molecule , biochemistry , in vitro , biology , chemistry , gene , oxygen , organic chemistry , myocardial infarction

Thrombolysis is a promising therapy for acute ischemic stroke. However, there is evidence that neutrophils may physically plug cerebral microvessels on reperfusion, preventing the full benefit of thrombolysis. We undertook this study to determine whether there was increased endothelial expression of the intercellular adhesion molecule-1 (ICAM-1) gene during hypoxia-reoxygenation.

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