Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment. | Zendy

Wayne M. Clark | Zendy; Fabien Calcagno | Zendy; Walter L. Gabler | Zendy; John R. Lindsay Smith | Zendy; Bruce M. Coull | Zendy

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Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment.

Author(s) -

Wayne M. Clark,

Fabien Calcagno,

Walter L. Gabler,

John R. Lindsay Smith,

Bruce M. Coull

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.7.1411

Subject(s) - medicine , doxycycline , neuroprotection , paraplegia , central nervous system , anesthesia , ischemia , spinal cord injury , in vivo , pharmacology , reperfusion injury , spinal cord , antibiotics , biochemistry , chemistry , microbiology and biotechnology , psychiatry , biology

Activated leukocytes appear to potentiate central nervous system reperfusion injury, and agents that block leukocyte adhesion have shown neuroprotective efficacy in experimental models. Doxycycline, a tetracycline antibiotic, inhibits leukocyte function in vitro, presumably through divalent cation binding. We used a model of focal central nervous system reperfusion injury to determine the efficacy of doxycycline treatment in preserving neurological function.

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