Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. | Zendy

Kazuo Kitazawa | Zendy; Tsuyoshi Tada | Zendy

Open Access

Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage.

Author(s) -

Kazuo Kitazawa,

Tsuyoshi Tada

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.7.1400

Subject(s) - cerebrospinal fluid , medicine , subarachnoid hemorrhage , hydrocephalus , communicating hydrocephalus , western blot , transforming growth factor beta , transforming growth factor , pathology , gastroenterology , endocrinology , surgery , biology , biochemistry , gene

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional polypeptide that controls the production of extracellular matrix protein. Platelets store a large quantity of TGF-beta 1, which is released at hemorrhage. We recently reported that human recombinant TGF-beta 1 induced communicating hydrocephalus in mice. The aim of this study was to determine whether TGF-beta 1 is related to the development of communicating hydrocephalus after subarachnoid hemorrhage (SAH).

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