Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. | Zendy

SeungChyul Hong | Zendy; Yasunobu Goto | Zendy; Giuseppe Lanzino | Zendy; Scott W. Soleau | Zendy; Neal F. Kassell | Zendy; Kevin S. Lee | Zendy

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Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

Author(s) -

SeungChyul Hong,

Yasunobu Goto,

Giuseppe Lanzino,

Scott W. Soleau,

Neal F. Kassell,

Kevin S. Lee

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.3.663

Subject(s) - calpain , medicine , ischemia , neuroprotection , saline , infarction , proteolysis , calcium , brain ischemia , anesthesia , middle cerebral artery , endocrinology , pathology , pharmacology , biochemistry , myocardial infarction , biology , enzyme

Excessive elevation of intracellular calcium and uncontrolled activation of calcium-sensitive events are believed to play a central role in ischemic neuronal damage. Calcium-activated proteolysis by calpain is a candidate to participate in this form of pathology because it is activated under ischemic conditions and its activation results in the degradation of crucial cytoskeletal and regulatory proteins. The present studies examined the effects of a cell-penetrating inhibitor of calpain on the pathological outcome after transient focal ischemia in the brain.

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