A comparison of intra-arterial and intravenous tissue-type plasminogen activator on autologous arterial emboli in the cerebral circulation of rabbits. | Zendy

Mark G. Hamilton | Zendy; J S Lee | Zendy; P J Cummings | Zendy; Joseph M. Zabramski | Zendy

Open Access

A comparison of intra-arterial and intravenous tissue-type plasminogen activator on autologous arterial emboli in the cerebral circulation of rabbits.

Author(s) -

Mark G. Hamilton,

J S Lee,

P J Cummings,

Joseph M. Zabramski

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.3.651

Subject(s) - medicine , thrombus , tissue plasminogen activator , anesthesia , embolization , ischemia , t plasminogen activator , fibrinolytic agent , stroke (engine) , cerebral circulation , surgery , cardiology , mechanical engineering , engineering

The efficacy of thrombolytic therapy for treatment of embolic stroke has been a subject of both experimental and clinical examination. The aim of this study was to compare the efficacy, in regard to reduction of volume of ischemic brain, of two different modes of administration (ie, intra-arterial and intravenous) of tissue-type plasminogen activator (TPA) given 30 minutes after experimental embolic stroke in rabbits.

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