Efficacious experimental stroke treatment with high-dose methylprednisolone. | Zendy

Gabrielle M. de CourtenMyers | Zendy; Marla Kleinholz | Zendy; K. R. Wagner | Zendy; Guohua Xi | Zendy; Ronald E. Myers | Zendy

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Efficacious experimental stroke treatment with high-dose methylprednisolone.

Author(s) -

Gabrielle M. de CourtenMyers,

Marla Kleinholz,

K. R. Wagner,

Guohua Xi,

Ronald E. Myers

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.2.487

Subject(s) - medicine , methylprednisolone , anesthesia , cats , stroke (engine) , cerebral blood flow , spinal cord , occlusion , edema , surgery , mechanical engineering , psychiatry , engineering

Recent studies reveal success in treating spinal cord trauma with early, high-dose methylprednisolone. As in spinal cord research, failure to find therapeutic effects with steroids in studies of acute stroke treatment may reflect institution of treatment too late and at too low dosage. We presently test the efficacy of stroke treatment with methylprednisolone administered early and at high doses using a cat temporary middle cerebral artery occlusion model.

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