L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. | Zendy

Eiharu Morikawa | Zendy; Michael A. Moskowitz | Zendy; Zhihong Huang | Zendy; Toshimichi Yoshida | Zendy; Katsumi Irikura | Zendy; Turgay Dalkara | Zendy

Open Access

L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.

Author(s) -

Eiharu Morikawa,

Michael A. Moskowitz,

Zhihong Huang,

Toshimichi Yoshida,

Katsumi Irikura,

Turgay Dalkara

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.2.429

Subject(s) - medicine , middle cerebral artery , cerebral blood flow , occlusion , anesthesia , vasodilation , nitric oxide , ischemia , infarction , blood flow , cardiology , myocardial infarction

We previously reported that L-arginine infusion increased pial vessel diameter by nitric oxide-dependent mechanisms, improved regional cerebral blood flow (rCBF) distal to middle cerebral artery (MCA) occlusion, and reduced infarction volume in spontaneously hypertensive rats when administered intraperitoneally before and after MCA occlusion. In this report we extend our findings (1) by examining the time course of L-arginine on rCBF and pial vessel diameter under basal conditions and on rCBF after MCA occlusion and (2) by reproducing the protective effect of L-arginine on infarct volume when given intravenously immediately after the onset of MCA occlusion in both normotensive and hypertensive models of focal cerebral ischemia.

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