Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. | Zendy

Paul G. Lysko | Zendy; C. L. Webb | Zendy; Tianli Yue | Zendy; Juan-Li Gu | Zendy; G Feuerstein | Zendy

Open Access

Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.

Author(s) -

Paul G. Lysko,

C. L. Webb,

Tianli Yue,

Juan-Li Gu,

G Feuerstein

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.12.2476

Subject(s) - neuroprotection , gerbil , medicine , tetrodotoxin , glutamate receptor , neuroscience , ischemia , excitotoxicity , cerebellum , pharmacology , receptor , biology

Studies examining the role of tetrodotoxin-sensitive ion channels in hypoxic-ischemic neuronal damage have concluded that sodium influx is an important initiating event. We examined the neuroprotectant effect of tetrodotoxin on both cultured cerebellar neurons and on CA1 hippocampal neurons of gerbils exposed to brain ischemia.

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