The perfluorocarbon fluoromethyloadamantane offers cerebral protection in a model of isovolemic hemodilution in rabbits. | Zendy

Damianos E. Sakas | Zendy; Robert M. Crowell | Zendy; KyungMann Kim | Zendy; Kazuyoshi Korosue | Zendy; Nicholas T. Zervas | Zendy

Open Access

The perfluorocarbon fluoromethyloadamantane offers cerebral protection in a model of isovolemic hemodilution in rabbits.

Author(s) -

Damianos E. Sakas,

Robert M. Crowell,

KyungMann Kim,

Kazuyoshi Korosue,

Nicholas T. Zervas

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.1.197

Subject(s) - medicine , anesthesia

Perfluorocarbons (PFCs) are considered promising cerebral protection agents because they could combine the beneficial effects of decreased blood viscosity with enhanced oxygen-carrying capacity and oxygen tissue delivery, but trials of PFCs as hemodilutants have been very limited. We evaluated fluoromethyloadamantane (FMA), a new perfluorocarbon compound, as an isovolemic hemodilutant and compared it with low-molecular-weight dextran 40 (D40) and a control group.

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