Influence of pH on calcium influx during hypoxia in rat cortical brain slices. | Zendy

B R O'Donnell | Zendy; Philip E. Bickler | Zendy

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Influence of pH on calcium influx during hypoxia in rat cortical brain slices.

Author(s) -

B R O'Donnell,

Philip E. Bickler

Publication year - 1994

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.25.1.171

Subject(s) - extracellular , hypoxia (environmental) , calcium , intracellular ph , intracellular , oxygene , calcium in biology , biophysics , fura 2 , biochemistry , endocrinology , medicine , chemistry , oxygen , biology , enzyme , cytosol , organic chemistry

Acidity of brain intracellular and extracellular fluids appears to increase brain injury from stroke, but low extracellular pH decreases the activity of N-methyl-D-aspartate receptor ion channels and decreases calcium influx into isolated neurons. To further investigate the role of acid-base balance in hypoxic brain injury, we studied the influences of intracellular and extracellular pH on calcium influx in cortical brain slices during hypoxia.

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