Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies. | Zendy

David C. Hess | Zendy; J.C. Sheppard | Zendy; Robert J. Adams | Zendy

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Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies.

Author(s) -

David C. Hess,

J.C. Sheppard,

Robert J. Adams

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.7.994

Subject(s) - medicine , antibody , immunology , umbilical vein , antiphospholipid syndrome , endothelial stem cell , endothelium , stroke (engine) , immunoglobulin g , pathology , biology , in vitro , biochemistry , mechanical engineering , engineering

There is a strong link between antiphospholipid antibodies and stroke. The mechanism of action of antiphospholipid antibodies is unknown. Most theories of pathogenesis center around platelet or endothelial cell dysfunction. Our aim was to determine if there were immunoglobulins in the sera of patients with antiphospholipid antibodies that bind human brain microvascular endothelial cells.

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