BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. | Zendy

M.J. Leach | Zendy; J. H. Swan | Zendy; D Eisenthal | Zendy; M Dopson | Zendy; M. S. NOBBS | Zendy

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BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

Author(s) -

M.J. Leach,

J. H. Swan,

D Eisenthal,

M Dopson,

M. S. NOBBS

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.7.1063

Subject(s) - glutamate receptor , pharmacology , neurotransmitter , medicine , cerebral cortex , acetylcholine , excitotoxicity , anesthesia , glutamic acid , biochemistry , biology , amino acid , central nervous system , receptor

The excitatory amino acid neurotransmitter glutamate is involved in excitotoxic brain injury and neurodegeneration after cerebral ischemia. Therefore, compounds that block the release of glutamate may be useful as cerebroprotective agents. The purpose of this study was to evaluate the cerebroprotective properties of a glutamate release inhibitor, BW619C89.

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