Tissue factor contributes to microvascular defects after focal cerebral ischemia. | Zendy

Winston S. Thomas | Zendy; Etsuro Mori | Zendy; Brian R. Copeland | Zendy; Jian-Qing Yu | Zendy; James H. Morrissey | Zendy; Gregory J. del Zoppo | Zendy

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Tissue factor contributes to microvascular defects after focal cerebral ischemia.

Author(s) -

Winston S. Thomas,

Etsuro Mori,

Brian R. Copeland,

Jian-Qing Yu,

James H. Morrissey,

Gregory J. del Zoppo

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.6.847

Subject(s) - medicine , middle cerebral artery , ischemia , occlusion , baboon , microcirculation , perfusion , pathology , cerebral arteries , tissue factor , cardiology , coagulation

Microvascular perfusion defects occur after occlusion and reperfusion of the middle cerebral artery in examples of focal cerebral ischemia. In addition to cellular (eg, polymorphonuclear leukocyte) contributors to the focal "no-reflow" phenomenon, activation of coagulation may also play a role. We have tested a potential role of tissue factor-mediated coagulation in the microvascular perfusion defects seen after focal cerebral ischemia-reperfusion in a baboon model of reversible middle cerebral artery occlusion with the murine anti-tissue factor monoclonal antibody TF9-6B4. Tissue factor is the principal resident procoagulant substance in cerebral tissues and has a distinct perivascular distribution.

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