Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. | Zendy

Yuichi Maruki | Zendy; R C Koehler | Zendy; Jeffrey R. Kirsch | Zendy; Kathleen K. Blizzard | Zendy; Richard J. Traystman | Zendy

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Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia.

Author(s) -

Yuichi Maruki,

R C Koehler,

Jeffrey R. Kirsch,

Kathleen K. Blizzard,

Richard J. Traystman

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.5.724

Subject(s) - medicine , ischemia , anesthesia , somatosensory evoked potential , acidosis , perfusion , lipid peroxidation , intracellular ph , cerebral blood flow , intracellular , oxidative stress , chemistry , biochemistry

Postischemic evoked potential recovery correlates with acidosis during ischemia and early reperfusion. Acidosis promotes lipid peroxidation in vitro. We tested the hypothesis that the 21-aminosteroid tirilazad mesylate (U74006F), an inhibitor of lipid peroxidation in vitro, ameliorates somatosensory evoked potential recovery and acidosis during reperfusion after severe incomplete cerebral ischemia.

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