Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. | Zendy

H. A. Kontos | Zendy; E. P. Wei | Zendy

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Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583.

Author(s) -

H. A. Kontos,

E. P. Wei

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.3.427

Subject(s) - superoxide dismutase , methylene blue , catalase , superoxide , nitric oxide , adenosine , pharmacology , chemistry , biochemistry , reactive oxygen species , radical , medicine , oxidative stress , enzyme , photocatalysis , catalysis

Methylene blue and 6-anilino,5,8-quinolinedione (LY83583) are used extensively to block activation of guanylate cyclase. Both agents generate oxygen radicals. Therefore, it appeared profitable to investigate whether the generation of oxygen radicals by these agents is responsible for the blockade of responses to nitrodilators that act via activation of guanylate cyclase to relax vascular smooth muscle and cause vasodilation.

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