Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats. | Zendy

Kazuo Minematsu | Zendy; M Fisher | Zendy; L Li | Zendy; Christopher H. Sotak | Zendy

Open Access

Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats.

Author(s) -

Kazuo Minematsu,

M Fisher,

L Li,

Christopher H. Sotak

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.12.2074

Subject(s) - medicine , magnetic resonance imaging , ischemia , anesthesia , perfusion , occlusion , infarction , perfusion scanning , middle cerebral artery , bolus (digestion) , nuclear medicine , radiology , myocardial infarction

Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and perfusion MRI to evaluate the in vivo effects of a noncompetitive NMDA antagonist, CNS 1102, in a temporary ischemia model.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research