Comparative effects of angiotensin-(1-7) and angiotensin II on piglet pial arterioles. | Zendy

Wei Meng | Zendy; David W. Busija | Zendy

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Comparative effects of angiotensin-(1-7) and angiotensin II on piglet pial arterioles.

Author(s) -

Wei Meng,

David W. Busija

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.12.2041

Subject(s) - angiotensin ii , arteriole , medicine , dilator , renin–angiotensin system , vasodilation , endocrinology , cerebral circulation , vasoconstriction , microcirculation , blood pressure

Recent investigations indicated that degradation fragments of angiotensins could be involved in the regulation of the cerebral circulation and that their effects might be mediated by prostaglandins. The present study was designed to examine the effect of angiotensin-(1-7), a major endogenous heptapeptide fragment, on cerebral arteriolar diameter and compare it with the octapeptide angiotensin II, and further to determine whether prostaglandins mediate their effects.

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