Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage. | Zendy

V. MacMillan | Zendy; Daniel P. Judge | Zendy; Amy L. Wiseman | Zendy; Deann C. Settles | Zendy; J L Swain | Zendy; James M. Davis | Zendy

Open Access

Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage.

Author(s) -

V. MacMillan,

Daniel P. Judge,

Amy L. Wiseman,

Deann C. Settles,

J L Swain,

James M. Davis

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.11.1735

Subject(s) - basic fibroblast growth factor , gerbil , medicine , transgene , hippocampal formation , genetically modified mouse , ligation , hippocampus , endocrinology , anesthesia , ischemia , growth factor , biology , gene , biochemistry , receptor

Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to resist the effects of severe cerebral hypoxemia-oligemia.

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