Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor. | Zendy

Kazuhiro Hiramatsu | Zendy; Neal F. Kassell | Zendy; Kevin S. Lee | Zendy

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Improved posthypoxic recovery of synaptic transmission in gerbil neocortical slices treated with a calpain inhibitor.

Author(s) -

Kazuhiro Hiramatsu,

Neal F. Kassell,

Kevin S. Lee

Publication year - 1993

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.24.11.1725

Subject(s) - calpain , neocortex , gerbil , depolarization , hypoxia (environmental) , calcium , neurotransmission , medicine , proteolysis , in vitro , neuroscience , pharmacology , endocrinology , ischemia , biology , chemistry , biochemistry , enzyme , receptor , organic chemistry , oxygen

Among the various calcium-induced biologic events occurring in hypoxic neurons, activation of the calcium-activated neutral proteinase (calpain) is a likely mediator of neuronal degeneration. In this study, we assessed the protective effects of a calpain inhibitor (Cbz-Val-Phe-H) against hypoxic damage to the neocortex.

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