Open AccessEffects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits.
Author(s) -
S H Johnson,
Joyce Kraimer,
Geoffrey M. Graeber
Publication year - 1993
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.24.10.1547
Subject(s) - medicine , flunarizine , anesthesia , spinal cord , ischemia , spinal cord injury , blood flow , neuroprotection , cord , hemodynamics , ketamine , surgery , pharmacology , cardiology , calcium , psychiatry
The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood flow, and neurological recovery in a rabbit model of ischemic spinal cord injury.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom