Open AccessLow blood-to-cerebrospinal fluid passage of sorbitol after intravenous infusion.
Author(s) -
Roland Nau,
T Dreyhaupt,
Herbert Kolenda,
Hilmar Prange
Publication year - 1992
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.23.9.1276
Subject(s) - cerebrospinal fluid , medicine , sorbitol , anesthesia , mannitol , pharmacokinetics , volume of distribution , cerebrospinal fluid pressure , cerebral edema , chemistry , biochemistry
Compared with mannitol, the osmotherapeutic agent sorbitol is less prone to accumulate in the blood and the same quantity may be infused in a smaller volume. Because of these advantageous characteristics, we studied the pharmacokinetics of sorbitol in serum and cerebrospinal fluid.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom