Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup. | Zendy

Laura R. Ment | Zendy; William Stewart | Zendy; Thomas Ardito | Zendy; Eunice Y. Huang | Zendy; Joseph A. Madri | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Indomethacin promotes germinal matrix microvessel maturation in the newborn beagle pup.

Author(s) -

Laura R. Ment,

William Stewart,

Thomas Ardito,

Eunice Y. Huang,

Joseph A. Madri

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.8.1132

Subject(s) - beagle , medicine , germinal matrix , laminin , basement membrane , saline , staining , pathology , andrology , endocrinology , extracellular matrix , biology , intraventricular hemorrhage , pregnancy , microbiology and biotechnology , genetics , gestational age

Although indomethacin has been demonstrated to prevent germinal matrix and intraventricular hemorrhage in clinical and animal studies, the mechanism of action of this agent to prevent hemorrhage remains unclear. Previous studies have demonstrated both that the microvessels in the germinal matrix of newborn beagle pups undergo basement membrane maturation during the first 4 postnatal days and that indomethacin may promote laminin deposition in tumor cell culture systems.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research