Polyethylene glycol superoxide dismutase and catalase attenuate increased blood-brain barrier permeability after ischemia in piglets. | Zendy

William M. Armstead | Zendy; R. Mirro | Zendy; O. Thelin | Zendy; Masaaki Shibata | Zendy; S. L. Zuckerman | Zendy; Douglas R. Shanklin | Zendy; David W. Busija | Zendy; Charles W. Leffler | Zendy

Open Access

Polyethylene glycol superoxide dismutase and catalase attenuate increased blood-brain barrier permeability after ischemia in piglets.

Author(s) -

William M. Armstead,

R. Mirro,

O. Thelin,

Masaaki Shibata,

S. L. Zuckerman,

Douglas R. Shanklin,

David W. Busija,

Charles W. Leffler

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.5.755

Subject(s) - superoxide dismutase , ischemia , medicine , superoxide , polyethylene glycol , blood–brain barrier , reperfusion injury , brain ischemia , endocrinology , biochemistry , anesthesia , chemistry , oxidative stress , central nervous system , enzyme

Transport of urea across the blood-brain barrier is increased during postischemic cerebral reperfusion in the piglet. Ischemia/reperfusion also has been observed to increase apparent superoxide anion generation on the surface of the brain. The present study was designed to address the hypothesis that the increased transfer of urea into the brain after ischemia/reperfusion could be due to superoxide anion-induced alterations in blood-brain barrier permeability.

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