Ischemic brain damage is not ameliorated by 1,3-butanediol in hyperglycemic rats. | Zendy

Jens Lundgren | Zendy; MajLis Smith | Zendy; A. M. Mans | Zendy; Bo K. Siesjö | Zendy

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Ischemic brain damage is not ameliorated by 1,3-butanediol in hyperglycemic rats.

Author(s) -

Jens Lundgren,

MajLis Smith,

A. M. Mans,

Bo K. Siesjö

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.5.719

Subject(s) - ketone bodies , medicine , ischemia , 2,3 butanediol , saline , endocrinology , brain ischemia , brain damage , metabolism , anesthesia , biochemistry , chemistry , fermentation

Treatment with the ketone body precursor 1,3-butanediol has been suggested to ameliorate hypoxic/ischemic brain damage. Butanediol could provide an alternative energy substrate for the brain, thereby decreasing the amount of glycolytically produced lactate. Hyperglycemia aggravates brain damage after brain ischemia and causes fatal postischemic seizures, probably by increasing the production of lactate and decreasing the pH. We studied whether butanediol treatment altered the adverse consequences following ischemia complicated by hyperglycemia.

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