A rat model of severe neonatal hypoxic-ischemic brain injury. | Zendy

Philip H. Schwartz | Zendy; Walid F. Massarweh | Zendy; Harry V. Vinters | Zendy; Claude G. Wasterlain | Zendy

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A rat model of severe neonatal hypoxic-ischemic brain injury.

Author(s) -

Philip H. Schwartz,

Walid F. Massarweh,

Harry V. Vinters,

Claude G. Wasterlain

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.4.539

Subject(s) - medicine , hippocampal formation , dentate gyrus , neocortex , ischemia , hypoxia (environmental) , brain damage , common carotid artery , anesthesia , infarction , hippocampus , pathology , ligation , carotid arteries , chemistry , organic chemistry , psychiatry , oxygen , myocardial infarction

Perinatal hypoxic-ischemic brain injury is a common problem with severe neurological sequelae. In this report we describe in detail a simple model of hypoxia-ischemia in the neonatal rat that gives rise to severe neocortical infarction and to selective hippocampal neuronal necrosis.

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