Study of platelet-mediated neurotoxicity in rat brain. | Zendy

R Joseph | Zendy; Chock Tsering | Zendy; K.M.A. Welch | Zendy

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Study of platelet-mediated neurotoxicity in rat brain.

Author(s) -

R Joseph,

Chock Tsering,

K.M.A. Welch

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.3.394

Subject(s) - platelet , medicine , thrombus , spinal cord , neurotoxicity , central nervous system , in vivo , secretion , ischemia , pharmacology , toxicity , biology , microbiology and biotechnology , psychiatry

The mechanism of ischemic neuronal injury is not fully resolved. The present view is that vascular occlusion per se does not fully account for the extent of neurological dysfunction. We previously hypothesized that platelet secretory products might contribute to neuronal injury in the central nervous system. Our preliminary studies using organotypic rat spinal cord cultures exposed to human platelet and its secretory products revealed that platelet products had neurotoxic properties.

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