Failure of GM1 ganglioside to influence outcome in experimental focal ischemia. | Zendy

S A Mayer | Zendy; W. A. Pulsinelli | Zendy

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Failure of GM1 ganglioside to influence outcome in experimental focal ischemia.

Author(s) -

S A Mayer,

W. A. Pulsinelli

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.2.242

Subject(s) - medicine , ischemia , edema , ganglioside , saline , cerebral edema , infarction , anesthesia , stroke (engine) , cerebral infarction , myocardial infarction , mechanical engineering , biochemistry , chemistry , engineering

Reports of improved short-term (less than 72 hours) outcome in experimental models of mechanical and ischemic central nervous system injury suggest that exogenous ganglioside administration may confer a protective effect on neural tissue. We studied the effect of the monosialoganglioside GM1 on cerebral infarction and edema in spontaneously hypertensive rats subjected to permanent focal cerebral ischemia.

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