Extracellular alkalinity exacerbates injury of cultured cortical neurons. | Zendy

Rona G. Giffard | Zendy; John H. Weiss | Zendy; DW Choi | Zendy

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Extracellular alkalinity exacerbates injury of cultured cortical neurons.

Author(s) -

Rona G. Giffard,

John H. Weiss,

DW Choi

Publication year - 1992

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.23.12.1817

Subject(s) - extracellular , neurotoxicity , glutamate receptor , endocrinology , medicine , calcium , toxicity , acidosis , biochemistry , pharmacology , biology , receptor

We have previously shown that extracellular acidity protects cultured fetal murine neocortical neurons from glutamate toxicity and combined oxygen-glucose deprivation injury, an action at least in part mediated by reduction in N-methyl-D-aspartate receptor activation. We now investigate the effect of extracellular alkalinity on both glutamate neurotoxicity and injury due to combined oxygen-glucose deprivation.

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