Open AccessCombined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil.
Author(s) -
Katherine Hewitt,
Dale Corbett
Publication year - 1992
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.23.1.82
Subject(s) - nicardipine , medicine , gerbil , dizocilpine , anesthesia , nmda receptor , ischemia , pharmacology , hypothermia , antagonist , calcium , receptor
Excessive activation of the N-methyl-D-aspartate receptor by glutamate produces an influx of Ca2+, which in turn is thought to lead to ischemic cell death. In this study we evaluated the combined treatment of the N-methyl-D-aspartate antagonist dizocilpine (MK-801) and the dihydropyridine Ca2+ channel blocker nicardipine for the reduction of hippocampal CA1 neuronal loss.
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